PMN.TO: Third Quarter 2019 Operational and Financial Results

By John Vandermosten, CFA



During 2019 the environment for β-amyloid (βA) focused Alzheimer’s Disease (AD) drug development has been on a roller coaster. In March, Biogen announced that its Phase III trials for aducanumab failed to reach their endpoints and the drug would be abandoned. This threw the AD space into chaos and investors pulled back investment from βA-focused work leaving apathy in its midst. Adapting to this environment, ProMIS Neurosciences Inc. (OTC:PMN.TO) shifted its resources towards strengthening their portfolio with candidates aiming at other neurodegenerative targets. Drug candidates were developed for α-synuclein in multiple system atrophy (MSA), Tau in AD and TDP-43 in amyotrophic lateral sclerosis (ALS). This flexibility has allowed the company to remain relevant despite rapidly chaning views on the target of choice.

Seven months after their discontinuation announcement, Biogen reversed itself and decided that it would pursue a Biologics License Application (BLA) for aducanumab based on further analysis of later data that became available. And now, ProMIS finds itself in a much stronger position with not only with a broad portfolio that can address a variety of neurodegenerative targets but also a dominant candidate for AD in PMN310.

During the third quarter and to date, ProMIS has added two new individuals to its Scientific Advisory Board, identified new antibodies for AD, MSA and ALS and pursued a private placement to provide capital as management discusses partnership opportunities with large pharmaceutical partners.

Financial results for 3Q:19 were provided in a press release and SEDAR filings released on November 13, 2019. The company continued to advance its platform expending $1.6 million1 in this effort. Research and development expenses were $1.1 million, a 44% reduction from prior year levels due to lower contract research organization (CRO) costs, decreased patent expenditures and decreased employee travel partially offset by higher consulting and professional fees and share-based compensation. General and administrative expenses were $0.6 million, also 44% lower year over year with the contraction attributable to decreased consultant salaries and associated costs, general corporate expenditures and share-based compensation.

As of September 30, cash stood at $0.4 million, falling $2.0 million compared to year end 2018. Cash burn for the first nine months of 2019 was ($4.7) million and ($0.9) million in the third quarter. On November 18, 2019, ProMIS announced that it had completed the first closing of its capital raise in the amount of CAD$2.1 million.

In the constantly changing and uncertain environment of neurodegenerative disease drug development, management has evolved its focus toward its drug discovery platform and highlighted three pillars in the company’s value proposition: 1) The root cause of many neurodegenerative diseases is already known, and drugs developed to address the diseases need to focus on the desired target and ignore other proteins. 2) Neurodegenerative diseases are caused by misfolded toxic forms of a protein which can be uniquely identified by ProMIS’ proprietary discovery platform. 3) Biomarkers can indicate whether a research program is on the right track early, before substantial capital is spent.

The company is sharing this refined mission with investors and prospective pharmaceutical partners, with whom they are carrying out discussions. While this pushes out our original forecasts for trial launches and ultimate sales, it does open up a wider variety of options that may move forward in the company’s portfolio.

Successfully pursuing an indication using biomarkers can be validated with clinical proof of concept trials in enriched populations which can generate meaningful data in six to twelve months for $5 to $10 million. The leading biomarker that ProMIS has identified is neurofilament light chain (NfL), which we discussed in further detail here. Not only has the marker proven itself in the lab, but it has also served as a valuable pharmacodynamic marker in multiple sclerosis and spinal muscular atrophy. We see tremendous value in this tool and anticipate it will support an endpoint in ProMIS’ future clinical trials.

Exhibit I – Neurofilament Light Chain Levels in Neurodegenerative Disease2

MSA, Tau & ALS

In early October, ProMIS announced that it had identified several antibody therapeutics that target toxic forms of α-syneuclein implicated in Multiple System Atrophy (MSA). The antibody candidates demonstrate a high binding coefficient to toxic alpha-synuclein aggregates present in patients diagnosed with MSA.

In a mid-October release, ProMIS demonstrated that several previously identified antibodies that are able to neutralize toxic oligomer forms of Tau protein can block the spread of pathogeic tau aggregate formation in a cellular model. ProMIS employed its discovery platforms to identify unique epitopes of these toxic forms then develop antibodies that can selectively bind to the toxic forms of Tau.

In late October, a set of antibody candidates were created that target the neurotoxic form of TAR DNA-binding protein 43 (TDP-43) This protein is found in all cells and associated with several diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The antibodies are uniquely matched to to misfolded intracellular aggregates of TDP-43 with no binding to normal TDP-43. The binding profile was confirmed in post-mortem brain tissue from FTD patients.


ProMIS is currently in confidential discussions with potential partners for the antibodies associated with the α-synuclein, Tau and TDP-43 targets. Each of these assets has at least two different prospects. While we do not anticipate a deal being announced prior to year end, we do think that of these potential partnerships, there should be a favorable agreement announced in 1H:20. The deal would enable ProMIS to move the partnered molecule towards the clinic and also provide capital via upfront payments to advance PMN310 into a Phase I trial. An equity capital raise and significant investment from a strategic partner are other mechanisms through which it can raise funds to advance the portfolio.

ProMIS has made it clear that they are seeking a partner to help develop the pipeline. The company’s unique platform to identify unique epitopes provides data that makes the therapeutic antibodies produced very valuable. Confidential discussions are currently underway with unidentified partners to develop these programs. The company entered into an agreement to raise CAD$6.5 million just prior to the third quarter report which will support operations until partnerships can be consummated.

Exhibit II – ProMIS Portfolio3

Additions to the Team

ProMIS has added several distingushed individuals to its advisory boards and management team over the last year. We see the additions as providing a diverse set of relationships, experiences and competencies to the group that will advance the AD, PD and ALS programs.

Timothy Rothwell was added to the Business Advisory Board in February. He has expierence as former U.S. CEO and Chairman for Sanofi-Aventis, CEO of Sandoz Pharmaceuticals and president of Rhone-Poulenc Rorer Pharmaceuticals. We see his experience and contacts in the industry as indispensable to making introductions to the decision-makers that comprise the opportunity set for partners in the ALS and PD program assets.

In June, C. Warren Olanow joined ProMIS’ scientific advisory board (SAB) scientific advisory board with considerable experience in neurodegeneration and PD, an area where he has authored over 300 publications. Dr. Olanow will work with the other members of the board to help guide develop the PD, AD and ALS programs.

Dr. Andre Strydom became a member of the SAB in August. His area of expertise is in Down syndrome where his research has advanced understanding in AD. Specific work includes investigation of biomarkers of cognitive decline including those related to excess amyloid production, oxidative stress, and neurodegeneration. Down syndrome patients show significant levels of amyloid in the brain and are at risk of early onset AD, making this an important population for PMN310 and an area likely to benefit from Dr. Strydom’s expertise.

Significant Event Timeline

ProMIS has a number of recent and upcoming milestones related to development of its pipeline which we summarize below.

‣ Confidential discussions with potential partners for platform programs – Ongoing

‣ CAD$2.2 million capital raise – January 2019

‣ PMN310 scale up manufacturing – 2019

‣ CAD$1.2 million capital raise – June 2019

‣ Prepare for IND and Phase I trial for PMN310 – 2019/2020

‣ Generate Phase I biomarker data – 2020

‣ CAD$6.5 million private placement – November 2019


ProMIS has continued to advance its programs, highlighting three new antibody advancements in October alone. Parallel with these endeavors is continued interaction with the scientific, investment and corporate community to present the potential of the company’s platform to garner KOL support, financing and partnerships. Management has refined its message highlighting the need to focus on the toxic forms of misfolded proteins that are the root cause of neurodegenerative disease and the importance of biomarkers that can rapidly and inexpensively demonstrate efficacy. We continue to be impressed with ProMIS’ discovery platforms and their ability to identify unique features of toxic misfolded proteins. We anticipate that a pharmaceutical partner deal or large investment will allow the company to advance its candidates into the clinic.

ProMIS represents an attractive opportunity to gain exposure to an immense disease area with no other approved disease modifying therapies. There are almost six million persons with AD in the US and over 30 million outside of the US that suffer from it. Additionally, there is a larger population with mild cognitive impairment (MCI) and pre-Alzheimer’s which may benefit even more from toxic oligomer sequestering therapy. The path forward is relatively clear with other assets setting the precedent for trial design and potentially accelerated approaches using biomarkers suggested by regulatory agencies. There is also substantial opportunity for drug development in PD, MSA and ALS.

Due to the volatile and uncertain environment following announcements related to aducanumab, the investment community is waiting to put new money to work in βA programs. This is despite evidence that other programs were focused on the wrong target and substantial research that supports toxic oligomers as the correct target. We continued to believe in the potential for PMN310 and the other candidates in development and the tremendous opportunity in AD and other neurodegenerative diseases due to the lack of effective therapies and the magnitude of the need.

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